NMN Pro 250™ Sustained Release - Uthever® NMN, 250 mg, 60 tabs - Living Machine™ - 3-Pack
SKU: 12783444221

NMN Pro 250™ Sustained Release - Uthever® NMN, 250 mg, 60 tabs - Living Machine™ - 3-Pack

Sale price$128.67 Regular price$142.97
Save 10%

Shipping Estimate
USA
  • USA
  • CAN

Ships within 48 hours · Estimated delivery Jul 7 - Jul 12

Promo Codes Available:

For Your Every Summer RSVP, with Code: SUMMER15

Description

NMN Pro 250™ Sustained Release - Uthever® NMN, 250 mg, 60 tabs - Living Machine™ - 3-PackCombat Aging, Improve Heart Health and Promote Muscle Strength NMN supplementation has been found to improve various parameters of health, including physical endurance and muscle strength, neurological function, heart health, body weight and gene expression. Nicotinamide mononucleotide (NMN) is a derivative of the B vitamin niacin that dramatically improves health and longevity by serving as a precursor to NAD+. NMN Pro 250 Sustained Release is

Combat Aging, Improve Heart Health and Promote Muscle Strength

  • NMN supplementation has been found to improve various parameters of health, including physical endurance and muscle strength, neurological function, heart health, body weight and gene expression.
  • Nicotinamide mononucleotide (NMN) is a derivative of the B-vitamin niacin that dramatically improves health and longevity by serving as a precursor to NAD+.
  • NMN Pro 250 Sustained Release is designed to slow and prolong NMN absorption, allowing a longer steady blood level concentration of the active ingredient. This enables NMN Pro 250 Sustained Release to be given at higher doses less frequently.

View Certificate of Analysis

Research Supported Benefits:

Supports Longevity. Studies have shown that boosting NAD+ synthesis in the body extends the lifespan of yeast, worms and flies. (1)

Blood Sugar Regulation. As we age, we have more trouble processing glucose, leading to higher blood sugar. Supplemental NMN is shown to improve several markers of skeletal muscle glucose metabolism that are commonly dysregulated in people with metabolic disorders. (2)

Supports Metabolism and Healthy Weight. Although excessive body weight can develop at any age, adults over age 40 are particularly susceptible to age-related weight gain as metabolism slows down and body composition is altered to favor fat over lean muscle. As obese individuals have reductions in both NAD+ levels and ATP (energy) production, replenishing NAD+ through NMN can help to reverse this while improving metabolic pathways to maintain a healthy weight. (3,4,5)

Supports Healthy Cognition. Declining cognitive function with age is related to a reduced NAD+ levels that impair mitochondrial function. Replenishing NAD+ stores through NMN may be able to prevent this dysfunction. (6,7)

Supports Healthy Skin. In our 30s and 40s, the appearance of our skin can start to show signs of age. Several studies have examined how boosting NAD+ levels in the skin prevents premature skin aging or supports a healthier external appearance. (8,9)

References:

1. Fang EF, Kassahun H, Croteau DL, et al. NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair. Cell Metab. 2016;24(4):566-581. doi:10.1016/j.cmet.2016.09.004

2. Feng Z, Qin Y, Huo F, et al. NMN recruits GSH to enhance GPX4-mediated ferroptosis defense in UV irradiation induced skin injury. Biochim Biophys Acta Mol Basis Dis. 2022;1868(1):166287. doi:10.1016/j.bbadis.2021.166287

3. Feng Z, Qin Y, Huo F, et al. NMN recruits GSH to enhance GPX4-mediated ferroptosis defense in UV irradiation induced skin injury. Biochim Biophys Acta Mol Basis Dis. 2022;1868(1):166287. doi:10.1016/j.bbadis.2021.166287

4. Gopi S, Balakrishnan P. Evaluation and clinical comparison studies on liposomal and non-liposomal ascorbic acid (vitamin C) and their enhanced bioavailability. J Liposome Res. 2021;31(4):356-364. doi:10.1080/08982104.2020.1820521

5. Katayoshi T, Nakajo T, Tsuji-Naito K. Restoring NAD+ by NAMPT is essential for the SIRT1/p53-mediated survival of UVA- and UVB-irradiated epidermal keratinocytes. J Photochem Photobiol B. 2021;221:112238. doi:10.1016/j.jphotobiol.2021.112238

6. Kim M, Seol J, Sato T, Fukamizu Y, Sakurai T, Okura T. Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study. Nutrients. 2022;14(4):755. Published 2022 Feb 11. doi:10.3390/nu14040755

7. Kiss T, Nyúl-Tóth Á, Balasubramanian P, et al. Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects. Geroscience. 2020;42(2):527-546. doi:10.1007/s11357-020-00165-5

8. Liao B, Zhao Y, Wang D, Zhang X, Hao X, Hu M. Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study. J Int Soc Sports Nutr. 2021;18(1):54. Published 2021 Jul 8. doi:10.1186/s12970-021-00442-

9. Mills KF, Yoshida S, Stein LR, et al. Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. Cell Metab. 2016;24(6):795-806. doi:10.1016/j.cmet.2016.09.013

10. Tarantini S, Valcarcel-Ares MN, Toth P, et al. Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice. Redox Biol. 2019;24:101192. doi:10.1016/j.redox.2019.101192

11. Wang X, Hu X, Yang Y, Takata T, Sakurai T. Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death. Brain Res. 2016;1643:1-9. doi:10.1016/j.brainres.2016.04.060

12. Yoshino J, Mills KF, Yoon MJ, Imai S. Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab. 2011;14(4):528-536. doi:10.1016/j.cmet.2011.08.014

13. Yoshino M, Yoshino J, Kayser BD, et al. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. 2021;372(6547):1224-1229. doi:10.1126/science.abe9985

Supplement Facts
Serving Size: 1 Tablet
Servings Per Container: 60
Amount Per Serving %DV
Uthever® β-Nicotinamide mononudeotide (NMN)
250 mg
† Daily Value not established
REV. 10.23
  • OTHER INGREDIENTS: Isomalt, modified pea protein, stearic acid, calcium palmitate, hydroxypropyl cellulose, pharmaceutical glaze.
  • SUGGESTED DAILY USE: Take 1 to 4 tablets in the morning, or as recommended by your healthcare practitioner.
  • NOTE: Store in a cool, dry place, away from direct sunlight. Do not use if tamper-evident packaging is broken.
  • DOES NOT CONTAIN: Dairy, egg, soy, wheat, gluten, corn, fish, shellfish, tree nuts, peanuts.
  • CAUTION: Not intended for use by pregnant or nursing women. Not formulated for use in children. If you have a medical condition or are taking medications, consult with your healthcare professional before using this product. KEEP OUT OF REACH OF CHILDREN 
  • Nicotinamide mononucleotide (NMN) is a derivative of the B-vitamin niacin that dramatically improves health and longevity by serving as a precursor to NAD+, a compound that plays a crucial role in energy production, metabolism and gene expression in the body. When we boost NMN levels in the body, we can enhance the biosynthesis of NAD+ and alleviate symptoms associated with depletion of this crucial nutrient. NMN supplementation has been found to improve various parameters of health, including physical endurance and muscle strength, brain health, heart health, body weight and gene expression.
  • NMN Pro 250 Sustained Release is designed to significantly enhance NAD+ production and absorption by raising NMN and NAD+ blood levels for up to 6 hours compared to approximately 6 minutes for non-stabilized NMN in animal studies. The gel barrier around the tablet effectively protects the NMN from harsh gastrointestinal acids and upon reaching the intestines can be released slowly.
  • Only Clincially-Proven NMN. ProHealth’s NMN is the only clinically-proven NMN to boost NAD+ levels in a peer-reviewed, double-blind, placebo-controlled, published, clinical study. Results of the study indicated a 38% increase in NAD+ levels and 12-year reversal in biological age.
  • Unique Delivery Method. NMN Pro 250 Sustained Release is designed to significantly enhance NAD+ production and absorption by raising NMN and NAD+ blood levels for up to 6 hours compared to approximately 6 minutes for non-stabilized NMN in animal studies. The gel barrier around the tablet effectively protects the NMN from harsh gastrointestinal acids and upon reaching the intestines can be released slowly.
  • Solvent-Free. Compared to other NMN products, ours is made without any chemical solvents.
  • Quality Manufacturing Practices. All of our products are manufactured in an FDA-registered, GMP-certified facility.
  • Third-Party Tested in the USA. Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.
Be Aware of Fake NMN: Fraudulent companies are always attempting to out-price competitors by using NMN fake ingredients to gain market share, which is not fair to you, the consumer, or the reputable companies, like ProHealth that spends time and resources to ensure a safe and pure NMN product.
Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 12783444221

Discover Niche Categories That Outsell

Top-Converting Item to Boost Your Average Order

4.2 ★★★★★
Based on 1140 reviews
Sort
Highest Rating
Newest First
Oldest First
Product Reviews
L
Verified Purchase
L
Pawtucket, US
★★★★★ 4
Toddler approved
Size: 4T-5T, Unit Count: 99
Fits true to size and easy to pull up and down by my toddler. Very absorbent - perhaps a little too absorbent as it's taking my daughter forever to be potty trained and she's content in her soiled training pants... Great quality overall.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on August 29, 2025
M
Verified Purchase
Marie33kl
Lowell, US
★★★★★ 5
They prevent leaks, and fit great!
We have always used Huggies diapers for our babies and young toddlers because they were the only ones that never leaked or caused a rash. My second daughter was fully potty trained at 2.5 years old and never needed pull-ups. However, our third daughter, who also trained at 2.5 years old, digressed with her nighttime potty training due to instability - we moved twice within the first 6 weeks after she potty trained. So we had to get pull-ups for her to wear at night. Obviously since we loved Huggies diapers, we tried Huggies Pull-Ups, and again, they did not disappoint! They never leak, even on nights when she doesn't get up to go at all, and has lots of pee, and they have never caused a rash either, no matter how full. She's been using them for 1.5 years, at night, and we have never had any issues. They are dependable: decently comfortable to the child, do not cause rashes, fit properly with the ability to adjust at the thigh (if needed), and they prevent leaks! I highly recommend them!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on January 19, 2025
K
Verified Purchase
Kathy
Fort Morgan, US
★★★★★ 5
Price good
Size: 5T-6T, Unit Count: 80
Perfect for starters
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 11, 2026
L
Verified Purchase
Larisa Thomason
Port Orchard, US
★★★★★ 5
Finally, a good night's sleep.
For almost a year, I've had sleep issues. No problem falling asleep, but I'd wake up 3 hours later and be up for the next 2-3 hours. I'd finally fall back asleep just a bit before the alarm and spend the rest of the day in a fog. It didn't matter whether I went to bed at 8:30 pm or 11pm - I was still up by 1:30-2 and awake for hours. It gradually got worse and I got desperate. A friend recommended Melatonin and I resisted at first, having tried it after our daughter was born (almost 15 years ago). The tablets I took then had some odd side effects and I only took them for a few weeks before throwing the bottle away. Now, I think I have have been taking far too high of a dose, because these 3mg tablets work great. Be careful when you take them! I'm awake and alert for about 20 minutes and then zone out totally - even in the middle of a conversation. After a couple of months, I've learned to just lay a tablet on my nightstand and take it when I'm ready to turn out the light. It works great: cured the problem of middle of the night sleeplessness. I still wake up sometimes at night, but have no trouble dropping back off to sleep. And when I wake up in the morning, I'm alert, energetic, and not already counting the hours until I can go back to bed to get a good night's sleep. For me, this supplement would have been a good buy at twice the price - and my family agrees. I'm rested, cheerful, and so happy I gave it a try. So far, no bad side effects. In fact, no side effects at all. I am taking it daily, but considering trying it on a more limited basis because of concerns about long-term effects. Considering, but haven't done it yet because I'm so enjoying a good night's sleep that I'm afraid to tinker with success! Although I saw results the very first night I took this, I waited to write a review just in case it was a placebo effect at work. But it's been 11 weeks and I'm confident that this product is really effective for me.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 2, 2012
M
Verified Purchase
Madelene Caselli
Port Orchard, US
★★★★★ 5
Time release.. ONLY way to go
Used this brand before... when refill needed, came back for more. Time release is the best way to go as it works all night. Not one big hit when you 1st go to sleep... A nice "hit"... to get you to sleep and then a slow release of the rest, to KEEP you asleep... Don't think you'll be disappointed. I use sustained release with any vitamin/supplement I take (assuming the company makes it) .. including this. It's the best way to allow your body to utilize the product.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 14, 2023

recommand products